2 Dimethyl sulfoxide(DMSO)
Dimethyl sulfoxide(DMSO) was first introduced in 1963 by a research team headed by Stanley W Jacob at the university of Oregon Medical School. This drug has many useful medical applications [Spring 1995]. Scientists at Washinton University,School of medicine, St Louis and university of Arakansas Department of Dermatology, was looking for a topical agent that would produce anaesthesia for painful surgery. 70% DMSO was reported as a most effective agent. DMSO is a potent scavenger of the free radical but maintaining normal integrity of cells and tissues. DMSO acts as synergistic drug with other therapeutic agents [Dake1967].
DMSO is bacteriostatic in 20% concentration against Escherichia coli, Staphylococcus sp and
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Antimicrobial drug resistance has prompted the development of several alternative strategies. Among these strategies, nanoscale materials, nanocomposites have emerged as significant and novel antimicrobial agents. Nanomaterials, typically 0.2–100 nm in size, have a high surface-to-volume ratio; this increases their interaction with microorganisms, which in turn improves their antimicrobial activity. Nanomaterials can be useful for in vivo and in vitro biomedical research and applications. The integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, molecular sensors and drug delivery vehicles. From all nanomaterials with antibacterial properties, metallic nanoparticles provide the best results. Several types of NPs, including various Molecules of 30 metal and metal oxides, have been developed and evaluated by different research groups; examples include silver (Ag), gold (Au), Ag oxide (Ag2O), zinc oxide (ZnO), titanium dioxide (TiO2), calcium oxide (CaO), copper oxide (CuO), magnesium oxide (MgO), and silicon dioxide
The chemical elements are divided into two broad groups, the metals and the non-metals. In this experiment, you will examine some members of the metal group and identify similarities and differences in their physical and chemical properties. Metals are the elements that are found in the left of the periodic table with high electrical and thermal conductivity. Metals lose electrons to create positive ion charges. Metals have a unique shine, are prone to forming, have a high tendency to form cations, and combine with oxygen to give mostly basic oxides.
Desomorphine or “Krokodil” made major headlines in the year 2002. This was when there were reports in Russia that showed abusers of the street drug had horrible side effects that resembled skin melting. The nickname is derived from the fact that users skin presents as a crocodile like look. On the streets desomorphine is a cheaper substitute for heroin. What causes such negative affects is not really the drug itself, but
Penicillin, is the first antibiotic that is medically used to fight off a large range of bacterial infection. For this experiment, we will be using ampicillin, it is a part of the penicillin drug group. The ampicillin inhibits the bacteria with the result of killing the bacterium or prevents it from multiplying. “When a bacterium multiplies, small holes open up in their cell walls as the daughter cells divide.
Museum about WW1 By Mats Peletier V4A 1226 words Subject 1: Mustardgas Mustard gas, or sulfer mustard, was often used in ww1. It has the ability to form large blisters on exposed skin and in the lungs. Within 24 hours of exposure to mustard gas, victims experience intense itching and skin irritation, which gradually turns into large blisters filled with yellow fluid wherever the mustard gas contacted the skin. Mustard gas vapor easily penetrates clothing fabrics such as wool or cotton, so it is not only the exposed skin of victims that gets burned.
The pain class of drugs makes up a huge portion of the global pharmaceutical market, specifically 300 million prescriptions, just second to cancer medication. This market is worth about $24 billion and a large portion of this market is made up of opioids1. Raw opium from the opioid plant was being consumed for pain purposes for hundreds of years from the early 1500’s to the early 1800’s. It was not until 1804 when German pharmacist, Friedrich Sertürner, isolated the alkaloid, Morphine, from the opium poppy plant with the purpose to make a drug with a safer alternative than consuming raw opium. Not only was Morphine the first opioid drug to be isolated straight from the opium poppy
Among those criteria mentioned above the intravenous medications, such as IV opioids, are well suited to fulfill the requirements. However, IV opioids have its drawbacks in that some patients may require such high doses of analgesia that there will be increased risk of respiratory arrest and loss of consciousness. These issues can be problematic in the early dressings change of superficial burns, while patient needs more frequent dressing change. In these cases, general anesthesia is the better solution to save the patient from
Many people do not realize that chemistry is a part of our day to day lives. One specific thing we see on a daily basis is the colors and paint people use in paintings, on buildings, and any other place paint could be. When this paint is developed, the people who make it have to decide exactly what the compound should be made up of. This is an important thing to consider when making these paints because as discussed in Chemistry 101 lab, compounds are different things that develop one item, in this case it is paint. They have to make sure that the paint is homogenous because if it was heterogeneous when being applied, the paint would not go on well.
The objective of this experiment was to use an aldol condensation reaction to synthesize 3-nitrochalcone from 3- nitrobenzaldehyde. This was accomplished with a Diels-Alder reaction that utilized 3-nitrobenzaldehyde, acetophenone, ethanol, and sodium hydroxide. The mechanism for the synthesis of 3-nitrochalcone is presented in Figures 1 and 2. The alpha carbon on the acetophenone is deprotonated. This is followed by the attack of the alpha carbon anion on the carbonyl carbon on the 3-nitrobenzaldehyde.
The results do not support the hypothesis that a higher surface area to volume ratio would result in sulphuric acid being diffused into the agar cubes in the shortest amount of time. This is evident in the results as the exact opposite to what was predicted occurred. Instead of the smallest cube with the largest surface area to volume ratio of 1cm3 having the quickest diffusion rate, it conversely took the longest at 0.092 cm3 per second, whilst the 2cm3 cube with 0.0384 cm3 per second took the least amount of time. This directly refutes the hypothesis. There was also no consistent trend evident in the results.
Introduction Chevron Phillips Chemical Company is the major producer of Cyclohexane. This successful company hoses the three largest cyclohexane plants in the world. Many are puzzled by how the production of cyclohexane seems to have become stagnant. Perhaps this is due to the cost of benzene increasing or the demand increasing. Through thorough investigation, the answer to this question and many more can be answered.
The field of nanotechnology explores the materials and their properties [28 -35 2-8], nanoscale of synthesized material when at least one dimension of the nanostructure is in one hundred nanometer range. Practically the materials in nanoscale have only few atoms or the clusters of atoms, and the properties of the materials have been found to be altered because of the quantum confinement effect. Nanomaterials have structural features in between to those of atoms and bulk materials. Nanomaterials exhibit a diversification of properties that are different and often significantly improved in comparison with those of
Properties of Ionic and Covalent Substances Lab Report Introduction The purpose of this lab was to determine which of the following substances: wax, sugar, and salt, are an ionic compound and which are a covalent compound. In order to accurately digest the experiments results, research of definitions of each relating led to the following information: ionic compounds are positive and negatively charged ions that experience attraction to each other and pull together in a cluster of ionic bonds; they are the strongest compound, are separated in high temperatures, and can be separated by polar water molecules. A covalent compound forms when two or more nonmetal atoms share valence electrons; covalent compounds are also
Aim: To find out the relationship between the greater concentration of sodium thiosulfate when mixed with hydrochloric acid and the time it takes for the reaction (the time it takes for the solution to turn cloudy) to take place and to show the effect on the rate of reaction when the concentration of one of the reactants change. Introduction: The theory of this experiment is that sodium thiosulfate and hydrochloric acid reach together to produce sulfur as one of its products. Sulfur is a yellow precipitate so, the solution will turn to yellow color while the reaction is occurring and it will continue until it will slowly turn completely opaque. The reaction of the experiment happens with this formula: “Na2 S2 O3 + HCL =
there is a critical need to better comprehend the PK and PD properties of fosfomycin keeping in mind the end goal to improve its utilization. In the event that this objective can be acknowledged fosfomycin may serve as a valuable treatment alternative for MDR contaminations, at any rate until more current operators get to be available.[31] 2.2.3 Chemistry and commercial formulations: Fosfomycin speaks to its own particular anti-infection class25 and is synthetically inconsequential to whatever other antibiotic.55 A phosphonic corrosive subordinate with the synthetic name (- )- cis-1,2-epoxypropylphosphonic corrosive and experimental equation C3H7O4P, it has the littlest sub-atomic weight (138 g/mol) of all antibiotics.[32,33] It contains
One of the possible systematic error that may occur in this experiment is that the hydrated (II) ammonium sulfate is contaminated as the iron (II) salt was left uncovered. The iron (II) salt was prepared by the lab assistant and the salt was left at the table uncovered for students to scoop the desired amount of salt they want. The iron (II) salt might be contaminated by dust particles and even saliva. This would cause the standard iron (II) solution to have less iron (II) salt in it and this means that less potassium permanganate solution is needed to titrate the iron (II) solution. This is a systematic error because the iron (II) solution used throughout the experiment.