Mitragyna speciosa or kratom is a tropical evergreen tree native in Southeast Asia and has been used in traditional medicine since the 19th century. However, the US Food and Drug Administration announced that the kratom plant has opioid properties and is unsafe for medical use.
People in certain regions, such as Thailand and Indonesia, define the plant as a medicinal herb used for chronic pain management, treatment of opioid withdrawal symptoms, and recreational activities. However, pharmaceutical experts classify it as an opioid because of its chemical components and warn people of the potential danger the plant can cause in human health.
The US FDA conducted a scientific analysis using a computational model to determine the compound in
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According to Hunter, both fentanyl and loperamide are opioids, but fentanyl is a very strong painkiller which is up to 100 times more potent than morphine, which can cause drug dependence. Loperamide does not cause euphoric effects unless taken in extra large doses. In kratom-related deaths, experts cannot precisely determine if the herb alone caused it because the people took something else after kratom consumption.
“Cases of mixing kratom, other opioids, and other types of medication is extremely troubling because the activity of kratom at opioid receptors indicates there may be similar risks of combining kratom with certain drugs, just as there are with FDA-approved opioids,” said Dr. Scott Gottlieb, Commissioner of the US FDA.
People who are taking kratom may experience one or more adverse effects such as nervousness, nausea and vomiting, sweating, itching, lethargy, and aggressive behavior. Chronic users exhibit severe adverse effects including thinness of the body, darkened skin, dryness of the mouth, constipation, and frequent urination. Abrupt cessation of kratom use or stopping cold turkey can cause withdrawal symptoms like joint and muscle pain, hostile behavior, watering of the eyes, and spastic limb movements. Kratom drug dependence can be treated in several ways including detoxification and cognitive behavioral
Identification of an Unknown Compound using Quantitative and Qualitative Analysis Lauren Tremaglio Chemistry 1011 Lab, Section 16 Instructor: Steven Belina October 3, 2014 Our signatures indicate that this document represents the work completed by our group this semester. Experimental Design and Discussion of Results The objective of this experiment was to identify an unknown compound through quantitative and qualitative analysis. In order to find the identity of the unknown compound, an initial qualitative test for solubility was performed.
If not used as prescribed, there is a significantly increased risk of harm. The symptoms of overdose from fentanyl include slow and problematic breathing, vomiting and nausea, a rise in blood pressure and
In recent readings about Cyntoia Brown, who according to Willingham, previously was a victim of human sex trafficking, is now serving a life sentence for murder. The source reports that Brown suffered from Fetal Alcohol Syndrome, grew up in an abusive home and ran away from her adoptive parent’s house prior to becoming involved in prostitution in Nashville. She was staying with different people and using drugs and alcohol. As a runaway, she then met a 24-year-old pimp named "Cut Throat," who eventually began physically and sexually abusing her, and forced her into prostitution according to Willingham. The article states that on August 7, 2004, Brown testified she was solicited for sex by 43-year-old Johnny Mitchell Allan, who picked her up near a Sonic parking lot and drove her back to his house.
Main side effects Respiratory depression, light headedness, sedation, dizziness, nausea and vomiting, constipation, abdominal pain. Patient education To take Morphine with meals to avoid abdominal cramps and nausea. To avoid driving and carry heavy machines.
Wheaton says his medication makes him heat-sensitive, have cotton mouth, head buzzes, and even dizziness. Even with these terrible side effects, he knows it is better than going without taking
Pharmacologists and biotechnologists fusing genomics are presently spinning more towards a customized medicine to encourage the endorsement of new medications and in addition to propel the medication improvement process. "Pharmacogenomics inspects the acquired varieties in qualities that manage drug reaction and investigates the ways these varieties can be utilized to foresee whether a patient will have a decent reaction to a medication, a terrible reaction to a medication or no reaction by any
“And do remember that a gramme is better than damn.” In the novel Brave New World by Aldous Huxley, drug use is regarded as part of daily life and often glorified by the characters. While the characters in Huxley’s novel have no problem using drugs to replace their emotions, prescription opioid abuse has become a major concern in the United States. Prescribing guidelines for these drugs need to be stricter in order to prevent prescription drug abuse from growing.
Another effective treatment option for opioid (opiate) addiction is a medication called Buprenorphine. Buprenorphine is an opioid medication similar to the ones prescribed for chronic pain and may still cause a person to have withdrawal when the treatment is started. When a health care provider mixes Buprenorphine with naloxone the mixture will block the feeling from the other opioids. The two medications put together are called suboxone. It acts as an opioid receptor in the brain that controls cravings and sickness from not having opiates.
" Protracted withdrawal is defined by SAMHSA as symptoms that mirror those felt during the early stages of acute withdrawal. These symptoms may occur immediately after the early stages of withdrawal or may be delayed for months after your initial recovery. While your withdrawal symptoms during this phase aren 't likely to be as severe as the initial pain of withdrawal, they can still be troubling. Typical protracted withdrawal symptoms include: Irritability Sudden depression Fatigue Lack of energy
Opioids are a prescription medication involving various forms of drugs, it can benefit patients as little as a few minutes, however, it can be extremely dangerous to patients without self-control. Morphine, heroin, oxycodone, and fentanyl are used for many different medical uses until companies started to combine these four ingredients into one small simple pill. The pill reduces chronic pain from a body in a matter of minutes taking a minimum dosage. The company that produces Opioids have discovered that for the most part opioids are healthier and safer than any other medications. Like other medications, opioids can also have its side effects too such as; sedation restlessness, respiratory depression, nausea, vomiting, constipation and much more.
( this is an analysis that is done by a Toxicologist).
In this lab, we tested 8 known ingredients to find what ingredients was in our unknown A and unknown B medications. We first tested the water solubility of our knowns and unknowns. We found that of the knowns, cornstarch and acetaminophen were the only ones not water soluble. The unknowns were also not water soluble. Th next test was the pH test.
The Daphne plant is a shrub that is popular in North America. Daphne, also known as spruge laurel, lady laurel, paradise plant and dwarf bay. This small shrub is about 1-1.5 meters in height. The Daphne plant blooms in early spring before the leaves appear. Sweet-scented rose-purple flowers cluster on the stem.
Computer models through softwares, make virtual human molecular structures, can predict the toxicity of chemicals and ingredients without bad and
Over half of side effects cannot be detected in lab animals. We don’t want to use animals but we don’t have any other options. Human clinic and epidemiology studies human tissue and Cell-baged research methods, cadavers, sophisticated high fidelity human patient simulators an computational models are more reliable to