Ameya J. Limaye PMCY 6510 Take Home Final Exam A. Reference drug product: Janumet XR (sitagliptin phosphate and metformin HCl extended release tablets) Selected dosage strength: 50mg sitagliptin, 500mg metformin (once daily for naïve patients currently not treated with metformin) B. Active pharmaceutical ingredients: 1. Sitagliptin: Sitagliptin is an orally-active inhibitor of the dipeptidyl peptidase-4 (DPP-4) enzyme. Inhibition of DPP-4 prevents breakdown of GLP-1and GIP and allows for an extended stimulation of insulin secretion, along with inhibition of glucagon secretion. This drives overall blood glucose towards a normal value. IUPAC name: (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H- [1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;phosphoric …show more content…
It is soluble in water and N,N-dimethyl formamide; slightly soluble in methanol; very slightly soluble in ethanol, acetone, and acetonitrile; and insoluble in isopropanol and isopropyl …show more content…
Limaye PMCY 6510 Take Home Final Exam Metformin hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) is a white to off-white crystalline compound with a molecular formula of C4H11N5•HCl and a molecular weight of 165.63. Metformin hydrochloride is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. Metformin belongs to BCS class III with high solubility and low permeability. This also allows for designing a controlled release formulation of metformin hydrochloride. However, due to the high dose amounts and dosing frequency, it has been a challenge to develop once daily metformin formulation. Metformin hydrochloride exists in a single stable crystalline form. There is one known polymorph of metformin hydrochloride, which exists only in a metastable state and hence is out of consideration of this formulation. C. Rationale: Selected dosage form is an extended release oral tablet. Metformin has a relatively short biological half-life of around 5-7 hours. Steady levels of metformin are required for a sustained suppression of glucagon release and insulin sensitization. This warrant multiple doses of metformin everyday for a patient each with a strength of at least 500mg. Majority of the patients being treated for the type 2 diabetes also take metformin in conjugation with some other therapeutic such as sulfonylureas or DPP-4 inhibitors. Hence, formulating an extended release dosage form of metformin along with a DPP-4
For processes that require dual sign-offs the following solutions are suggested: For In Process Inspections (IPI) and In-Process Secondary Production Acceptance Certification (PAC): Option 1: Place a quality plan on the operation that requires the IPI or PAC. The benefits are reduced work orders and reduced steps while capturing an approver’s name. The downside as mentioned in the problem description is “there are no restrictions, so the same person can sign off both blocks in the plan.” Option 2: At the route level, plan a separate operation for the secondary approval sequenced after the operation performing the work to be certified.
line from x = y to y = x. Mathematically, x = y and y = x mean the same thing. How- ever, this is not so in programming. Run the second program.
Good Morning all, The confusion continues… Per the DOE, the Admin Supports are now required to the complete the Inpatient reporting class via TLC (RPT0-can be typed in the search field on the TLC page). Users will need to register and choose all of the classes associated with the registration before clicking on the submit button. Once they have completed all of the required classes and passed the assessment Epic security will be notified and access will be granted.
Mykah Sanchez PSY366 T&TH 9-10:15am Assignment 3 1. What are three differences you notice between these five different sets of diagnostic criteria? a. In the DSM-IIIR (APA, 1987) and on, the content of the obsession is not related to the actual compulsion if the patient also acquires another disorder in Axis I. In the DSM I & II, it does not specify if the compulsion is or should be related to the obsession.
Thanks Justin & Devon, Devon, I am able to pull data into PI and I have verified it with our S1 and S3 data records. The trick is to adjust the time range from the special function button in the PI instead of manually adjusting the date and data time range which is slow and makes PI unresponsive for few minutes. Regards, Nakul
Over the past year, the GEMS Project has worked with stakeholders across SAMHSA to conduct a comprehensive Lean Assessment of the agency’s grants processes. Currently, GEMS Group II (Policy and Procedures) and SAMHSA grants subject matter experts (SMEs) are using SAMHSA grants process workflows to conduct value stream mapping (VSM) sessions (see example in Appendix I). Group II is then analyzing the sessions’ outcomes to recommend specific procedure (P&P) and/or system-level (IMPAC II) changes before IMPAC II is implemented and legacy systems are sunset. This process has been developed to directly support grants processes streamlining and reduce expected operational disruptions throughout the new system adoption. This brief outlines the Lean
Works Cited Broida, Rick. “Does it still make sense to build your own computer?” C Net. C Net, 13 May 2013. Web.
Ms. Vidakovic, I hope this information was helpful. Once I receive the information above we can begin to work on a resolution. . I also would like to notify you that as part of Comcast 's goal to empower our customers you can also trouble shoot your service errors at home from the XFINITY.com website and the XFINITY My Account App. If you have any question or concerns, please respond directly to this email.
Answer each of the following questions within a full and complete sentence. Do not provide the information as a list or as bulleted items What are the mailing address and telephone numbers that should be used to contact you in case of an emergency? Include the full address and telephone number in a complete sentence form. A comma is required between the street address and the city.
TU170 STUDENT NAME : SALIM SAUD ALAZWANI STUDENT NUMBER : 140716 Q1: Q2: 1) plug-in(computing) we may say it 's program that 's help you to bring data or information from global internet. and we may call it program piece of software code that 's help application or program it could not by itself. plug-ins do things very fast because it 's actually sorts things such as help you to watch video online, listen to online music or radio and play many online games. sometimes we don 't need it but your computer will offers you plug-in and it 's easy app to download if you follow the instructions on the screen.
PSY 150 Homework Assignment 1: Answer the following questions with at least two complete sentences each. Provide enough details to show how much you understand the topic being discussed. Use your own words. Imagine that someone claims she can interpret your dreams or can speak to the dead. How could critical thinking help you check her claims?
HIST 1111 Study guide for the HIST 1111 Final Exam: As you can see from the list of questions our final examination will not be fully comprehensive, that is, not all sections we have studied will be on the final examination. Students should be familiar with the answers for the following questions if asked about them in a multiple choice, matching, and/or short answer format: 1.What were characteristics of the Neolithic Age? 2.What civilization invented the concept of zero? 3.What were the geographical features that influenced Mesopotamia? 4.What were the several characteristics of Sumerian city-states we discussed in class?
Hw #2 Ch 14 Review Questions and Exercises, P 879: 1, 7, 10, 20, 38, 43, 45, 52, 60, 62; Programming Challenges, P 884: 4, 5, 6. Describe the difference between an instance member variable and a static member variable. The main difference between an instance member variable and a static member variable is each class object has its own copy of class’s instance member variables. If a class’s member variable is static, however, only one instance of the variable exists in memory.
In chapter five, Greene and Lee (2011) discuss about the importance of goals and how to define the goals from the client’s perspective. There are a couple of questions that a practitioner can use to help define the goals for the individual, or in the case a group. I could select a couple of different questions to help define the goals of this group. There are two questions that I feel might work well to define goals for this group. The first question I would ask to the group members would be in the form the time travel format.
Upwards Wen Yue (Steven) Yang 68672435 CRWR 200 Assignment 2 Genre Fiction The team would begin the descent today. It would take at least two weeks for us to reach the bottom of the tower, from the spiral platform protruding from the tower’s side. Then another week would pass before we could arrive at the newly discovered lands where we were called to examine the soil and clay. Most workers, including myself, did not go down very often, usually in years, unless something happened.