Therefore, liquid-liquid and acid-base extraction techniques were successfully performed to separate the components of the Excedrin tablet. According to the TLC analysis results, the compounds (aspirin, acetaminophen, and caffeine) were successfully isolated from the analgesic (Excedrin tablet). In figure 1, the separation of the compound in the TLC analysis correlates with the TLC analysis in figure 2. Furthermore, Rf index calculations of the TLC analysis demonstrated that the compounds (aspirin, acetaminophen, and caffeine) were separated. The Rf calculations of aspirin in table 1 shows an Rf value of .491; however, in table 2 the Rf value of aspirin was calculated to be .784. This Rf value is the higher among the other compounds because the Rf values decreases from aspirin to caffeine; therefore, this suggests that the …show more content…
Thus, a higher percent yield was calculated for acetaminophen. Although, a second filtration was performed; however, a very low concentration of acetaminophen was recovered as a result of human errors, and the transfer of solution/solid contributed to product loss. However, the mass use to calculate percent yield was the first mass recorded because it may be more consistent than the mass measured after the second filtration. However, for further experiments, the percent yield must be calculated with the corresponding mass of product (actual yield) even though there is loss of product, the actual yield is the final concentration of the recovered product in the experiment. Thus, the results may be more conclusive if the actual percent yield was used. However, in this particular experiment, despite this deviation, aspirin, caffeine and acetaminophen compounds were successfully isolated from the analgesic
The last goal was to determine the percent yield of a product formed during a reaction with the unknown compound. Experimental Design The first day of lab consisted of various preliminary tests that helped identify the unknown compound.
Lab Report 5: Acetylsalicylic Acid (Aspirin) Synthesis Name: Divya Mehta Student #: 139006548 Date Conducted: November 19th 2014 Date Submitted: November 26th 2014 Partner’s Name: Kirsten Matthews Lab Section: Wednesday 2:30 L9 IAs Name: Brittany Doerr Procedure: For the procedure, see lab manual (CH110 Lab Manual, Fall 2014) pages 96-98. Wilfrid Laurier University Chemistry Department. Fall 2014. Acetylsalicylic Acid (Aspirin) Synthesis.
Audience: This paper is written with the intent of addressing an audience consisting of advanced high school students and lower division college students, who are interested in learning what happens to their bodies internally when ibuprofen is consumed. Students should have taken a general chemistry, and biology course as a prerequisite. It is expected that the student have some previous knowledge on nomenclature, spectroscopy, and basic internal organs.
This piece of evidence is not so compelling because the pH levels dropped for all drugs after the HCl was added because stomach acids neutralize the pH levels (“Painkillers & Acid Reflux Symptoms”). The most compelling piece of evidence is the color when we added the iron nitrate. They both turned black when the iron nitrate was added and no other pain reliever looked like those two. Unknown B is Bufferin because they both look like white powders and they were both insoluble. When the universal indicator was added they both turned orange, which indicted their pH level was 5.0.
Leah Romero 10/30/2017 Conclusion Lab 3 Chem 102L In lab 3, fundamentals of chromatography, the purpose was to examine how components of mixtures can be separated by taking advantage of different in physical properties. A huge process in this lab was paper chromatography, which was used to isolate food dyes that are found in different drink mixes. The different chromatograms of FD&C dyes were compared to identify which dyes are present in each of the mixes.
And as we define HPLC (High performance liquid chromatography) and formerly known as high pressure liquid chromatography, is a classical quantitative analysis method by which we use pump in a pressurized liquid to extract the mixture and get the sample of caffeine content of soft drinks. Through this method we will able to analyze the caffeine contain. There are disadvantage and advantage of having caffeine in soft drinks by ingesting it. It brings alertness and awakens our system and repel adenosine
If these tests can be further developed in order to become more popular, more efficient it can lower the cost of production and cause less pollute to environment. Caffeine was extracted from tea by the use of solid-liquid and liquid-liquid extractions. An acid/base liquid-liquid extraction took place in order to force caffeine into the organic
3. In this experiment, the percent yield was 90%. This number implies that there was little error in this experiment. However, this result could have been caused by certain external factors.
The main objective of this experiment was the formation of phenacetin from the synthesis of acetaminophen. This was done through a chemical reaction known as the Williamson ether synthesis using techniques of refluxing, vacuum filtration and recrystallization incorporating a mixed solvent system. A further objective of this experiment was to study the formation of the product (phenacetin). Such validation was completed by using techniques for determining the melting point, calculating percent yield, and IR (infrared spectroscopy) of the resultant product.
A 5.0 mM stock solution of acetaminophen was prepared by dissolving an appropriate amount of the powder in a small
TLC was used to identify the actual unknown product as well as other products/reactants present in the filtered solution. The procedure was conducted by placing a TLC plate in a developing chamber that is filled with a small amount of solvent. The solvent cannot be too polar because it will cause spotted compounds on the TLC plate to rise up too fast, while a very non-polar solvent will not allow the spots to move. The polarity of the spots also determines how far it moves on the plate; non-polar spots are higher than polar ones. After spots on the TLC form, the Rf values are calculated and used to analyze the similarity of the compounds.
One of the reasons why SPE is a suitable technique for this analysis is the fact that there should be higher recoveries (% recoveries)since both caffeine and theophylline are polar compounds, with theophylline being more polar than caffeine which tells us that caffeine will have the longer retention time than theophylline. Other reasons include advantages such as SPE provides cleaner extracts and is easier to automate compared to other extraction
According to KnowYourDose.org, an online campaign that seeks to educate consumers about proper intake of the drug acetaminophen, “Acetaminophen is the most common drug ingredient in America, and there are more than 600 medicines that contain acetaminophen.” Not only does this one active ingredient relieve pain, the FDA.gov states that it also aids in alleviating other health problems such as allergies, colds, and sleeplessness. Acetaminophen seems to be a powerful drug that many people seriously depend on– but that’s not the problem. II. Need:
Experiment #1 Isolation of Caffeine from Tea Date: 11.09.14 Prepared by: Alibek Abilev Purpose The aim of the experiment was to isolate crude caffeine from tea leaves by using liquid – liquid extraction with methylene chloride, purify the crude substance by performing sublimation and determine the melting point of both crude and pure caffeine. Safety Lab coat, goggles, gloves. Methylene chloride is a carcinogenic substance, therefore should be kept in a well-ventilated place.
The mean percentage recovery was found in the range of 101.1%-101.84% and 101.84-102.84% for the Absorbance correction method and 99.93-101.14 and 101.62-102.57 for the absorbance ratio method, for ibuprofen and Famotidine respectively at three different levels of standard additions. The precision (intra-day, inter-day) of methods were found within limits (RSD s law in the concentration range of 20-140μg/mL and 2-10μg/mL for ibuprofen and famotidine